The overarching mission of this center is to advance research in digestive disease with a focus on interactions between host and environment. The WU-DDRCC seeks to advance the health of patients with digestive diseases by supporting enabling technology and promoting the basic and translational research interests of its 49 full + 11 associate members. These interests are organized around three major themes, including: (1) Host-microbial interactions, inflammation and mucosal immunity; (2) Stem cells, development, epithelial renewal, and cancer biology; (3) Nutrient transport, metabolism and signaling.
Our Central Hypothesis is that advances across the spectrum of clinical care of patients with digestive diseases requires a community of basic and translational investigators to advance understanding of disease pathways and mechanisms, to promote scientific collaboration and synergies and ultimately to identify new therapeutic opportunities with the potential for rapid translation into clinical trials.
This Central Hypothesis will be pursued through the following SPECIFIC AIMS:
1. Provide a responsive Administrative core that promotes collaborative and synergistic interactions between investigators from multiple disciplines engaged in digestive disease related research with a focus on interactions between host and environment.
2. Organize and support Core laboratories and services that provide state-of-the-art services and specialized expertise that would otherwise not be available to individual investigators, in a cost-effective manner.
3. Provide a scientific Enrichment program sponsoring visiting researchers and workshops to augment the scientific milieu,promote collaboration and stimulate development of new initiatives in digestive disease.
4. Support a professional academic training program that promotes the interests and development of graduate students, postdoctoral trainees, housestaff, fellows and junior faculty as well as allied health professionals to pursue careers in digestive disease research.
5. Identify, support and nurture new investigators interested in digestive disease research through an annual Pilot and Feasibility awards program.
6. Promote and share technology development with other DDRCCs regionally and nationally.
If you are interested in joining the Washington University School of Medicine's Digestive Diseases Research Core Centers (DDRCC), please click here for more information.
Associate Director: Jason Mills, M.D., Ph.D., Associate Professor of Medicine, Pathology and Immunology and Developmental Biology
Administrative Contact: Anastasia Zylka
Webmaster: Jean Wang, M.D., Ph.D.