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R. Reid Townsend, M.D., Ph.D |
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Washington University Dept. of Internal Medicine tel: (314) 362-7709
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RESEARCH INTEREST Our research interests are in proteomics, which is the study of the range of proteins and protein interactions in healthy and diseased cells. Ongoing efforts are directed at evaluating new mass spectrometric and high-throughput protein technologies and developing novel software that integrates genomic and proteomics data and that uses proteomic information to identify genes. Current projects involving DDRCC members include the following: 1.) identification of cohort of proteins that mediate human-bacterial symbiosis (Gordon); 2.) identification of protein differences that distinguish pathogenic Entamoeba histolytica from nonpathogenic Entamoeba dispar (Stanley); identification of serum diagnostic and classification biomarkers in infants with biliary atresia (Heuckeroth, Biliary Atresia Research Consortium); proteomic analysis of two types of enteroendocrine cells, one that produces glucose-dependent insulinotropic peptide and one that produces chromogranin A (Wice) SELECTED PUBLICATIONS Adam PJ, Boyd R, Tyson KL, Fletcher GC, Stamps A, Hudson L, Poyser HR, Redpath N, Griffiths M, Steers G, Harris AL, Patel S, Berry J, Loader JA, Townsend RR, Daviet L, Legrain P, Parekh R, Terrett JA. Comprehensive proteomic analysis of breast cancer cell membranes reveals unique proteins with potential roles in clinical cancer. J Biol Chem. 2003 Feb 21;278(8):6482-9. Page MJ, Amess B, Townsend RR, Parekh R, Herath A, Brusten L, Zvelebil MJ, Stein RC, Waterfield MD, Davies SC O'Hare MJ, Proteomic definition of normal human luminal and myoepithelial breast cells purified from reduction mammoplasties. Proc Natl Acad Sci U S A 1999: 96:12589-12594. .Johnson PJ, Poon TC, Hjelm NM, Ho CS, Ho SK, Welby C, Stevenson D, Patel T, Parekh R Townsend RR, Glycan composition of serum a-fetoprotein in patients with hepatocellular carcinoma and non-seminomatous germ cell tumour. Br J Cancer 1999: 81:1188-1195. |
