William F. Stenson, M.D.

RESEARCH INTEREST

We have a longstanding interest in intestinal inflammation. This laboratory has focused on the roles of lipid mediators of inflammation (prostaglandins, leukotrienes and platelet activating factor) in the pathogenesis of intestinal inflammation in general, and human inflammatory bowel disease in particular. In particular, we are interested on the effects of prostaglandins on intestinal epithelial function. We have used the radiation injury model to study the effect of prostaglandins on stem cell survival and crypt cell apoptosis. We have also investigated the regulation of cyclooxygenase expression in the intestine in response to radiation and fibroblast growth factors. In collaboration with Dr Rodney Newberry, we have investigated the role of prostaglandins in regulating the mucosal immune response in the intestine. Finally, in collaboration with Dr Greg Gurtner, we have investigated the role of indoleamine-2,3-dioxygenase in regulating the intestinal immune response.

SELECTED PUBLICATIONS