<html> <head> <title>John J. Lehman, M.D.</title> </head> <body bgcolor="#000000"> <h1 align="center"><img src="../images/Fac_Res_Int.gif" width="640" height="150"></h1> <table width="771" border="0" align="center"> <tr> <td height="47" width="191"> <div align="center"></div> </td> <td height="47" width="10"> <p align="center">&nbsp;</p> </td> <td height="47" width="556"> <p><font size="5"><b><font color="#FFFFFF">John J. Lehman, M.D.</font></b></font></p> </td> </tr> <tr> <td valign=top width="191" height="150"> <font color="#FFFFFF"> <p align=center><img src="../images/faculty/lehman.jpg" width="119" height="178"> </p> <p align=center><font size="+1">Washington University<br> School of Medicine</font></p> <p> Cardiovascular Division<br> Box 8086<br> 660 S. Euclid Ave.<br> St. Louis, MO 63110</p> <p>tel: (314) <font size="+1">362-8660</font><br> fax: (314) <font size="+1">362-0186</font><br> email: <a href="mailto:jlehman@wustl.edu"><font color="#FFFFFF">jlehman@wustl.edu</font></a><br> <font color="#FFFFFF">web: <a href="http://wuphysicians.wustl.edu/physician2.asp?PhysNum=3143"><font color="#FFFFFF">Personal Weblink</font></a></font></p> <p>&nbsp; </p></font> </td> <td width="10" height="385">&nbsp;</td> <td width="556" height="385"> <p><font color="#FFFFFF"><b><font color="#FFFF00">RESEARCH INTEREST</font></b> </font></p> <p align="justify"><font color="#FFFFFF">We are investigating how calorie restriction and other dietary modifications influence mitochondrial metabolism and overall organismal aging. In particular, we are investigating the influence of the key transcriptional regulators PGC-1&alpha; and PPAR&alpha; on mitochondrial function, calorie restriction, and aging.</font></p> <p><font color="#FFFF00"><b>SELECTED PUBLICATIONS</b></font></p> <font color="#FFFFFF"> <p>Leone,T.C., Lehman, J.J., Finck, B.N., Schaeffer, P.J., Wende, A.R., Boudina, S., Courtois, M., Wozniak, D.F., Sambandam, N., Bernal-Mizrachi, C., Chen, Z., Holloszy, J.O., Medeiros, D.M., Schmidt, R.E., Saffitz, J.E., Abel, E.D., Semenkovich, C.F., Kelly, D.P. PGC-1α Deficiency Causes Multi-system Energy Metabolic Derangements: Muscle Dysfunction, Abnormal Weight Control and Hepatic Steatosis. PLoS Biology (2005) 3(4): e101.</p> <p>Mancuso, D.J., Han, X., Jenkins, C.M., Lehman, J.J., Sambandam, N., Sims, H.F., Yang, J., Yan, W., Yang, K., Green, K., Abendschein, D.R., Saffitz, J.E., Gross, R.W. Dramatic Accumulation of Triglycerides and Precipitation of Cardiac Hemodynamic Dysfunction During Brief Calorie Restriction in Transgenic Myocardium Expressing Human Calcium-Independent Phospholipase A<sub>2</sub>&gamma; The Journal of Biological Chemistry (2007) 282, 9216-9227.</p> <p>&nbsp;</p> </font> </td> </tr> </table> <h1>&nbsp;</h1> <h1>&nbsp;</h1> <h1><font size="+1"><BR> </font></h1> </body></html>