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| David H. Alpers, M.D. | |
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Washington University
Dept. of Medicine tel: (314) 362-8943
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RESEARCH INTEREST Our laboratory research interests have involved the synthesis, secretion and transcytotic movement of intestinal proteins and the regulation of these processes, including the role of cobalamin (vitamin B-12) binding proteins in the absorption of the vitamin. Current emphasis is on transferring this laboratory experience to clinical investigation in patients with nutritional problems. This effort will be combined with my role as assistant director of the Clinical Nutrition Research Unit, and my long-standing clinical research interest involving the recognition and treatment of psychiatric disorders in clinical gastroenterology, particularly as they interact with irritable bowel syndrome and inflammatory bowel disease. SELECTED PUBLICATIONS Gordon MM, Brada N, Remacha A, Badell I, del Rio E, Baiget M, Santer R, Quadros EV, Rothenberg SP, Alpers DH. A genetic polymorphism in the coding region of the gastric intrinsic factor gene (GIF) is associated with congenital intrinsic factor deficiency. Hum Mutat. 2004; 23: 85-91. Mahmood A, Shao JS, Alpers DH. Rat enterocytes secrete SLPs containing alkaline phosphatase and cubilin in response to corn oil feeding. Am J Physiol Gastrointest Liver Physiol. 2003; 285:G433-41. Mahmood A, Engle MJ, Alpers DH. Secreted intestinal surfactant-like particles interact with cell membranes and extracellular matrix proteins in rats. J Physiol. 2002 Jul 1;542(Pt 1):237-44. Miller AR, North CS, Clouse RE, Wetzel RD, Spitznagel EL, Alpers DH. The association of irritable bowel syndrome and somatization disorder. Ann Clin Psychiatry. 2001; 13: 25-30. |
